Photo-controllable nitric oxide releasers and biological applications
نویسندگان
چکیده
منابع مشابه
Structure-activity relationships of spontaneous nitric oxide releasers, FK409 and its derivatives.
(+/-)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide (FK409) shows both potent in vitro vasorelaxant and antiplatelet activities via nitric oxide (NO) generated spontaneously from the compound. In this study, we measured spontaneous NO-releasing rates of a series of FK409 derivatives, of which chain lengths or substituents were systematically modified, in sodium-phosphate buffer solution...
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DETC: diethyldithiocarbamate, DMPO: 5,5-dimethyl-1-pyrroline N-oxide, DNIC: di-nitrosyl-iron complex, DTCS: N-(dithiocarboxy)sarcosine, EDRF: endothelium-derived relaxing factor, EPR, ESR: electron paramagnetic resonance; electron spin resonance, cGMP: cyclic GMP, Hb: hemoglobin, LPS: lipopolysaccharide, Mb: myoglobin, MGD: N-methyl-D-glucamine dithiocarbamate, MNIC: mono-nitrosyl-iron complex,...
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Oxygen-derived free radicals play a major role in the physiology and pathology of the vessel wall [1]. To assess superoxide anion production (O2) from endothelium, four techniques are mainly used: reduced cytochrome c UV-visible absorption [2,3], ESR spin trapping [4,5], hydroethydine fluorescence [6] and lucigenin-enhanced chemiluminescence [7,8]. The simplest technique which has been used for...
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ژورنال
عنوان ژورنال: Drug Delivery System
سال: 2016
ISSN: 0913-5006,1881-2732
DOI: 10.2745/dds.31.127